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. 2018 Jul 9;8:10360. doi: 10.1038/s41598-018-28511-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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il10^e46/e46 mutant zebrafish have reduced inflammation in a chronic mycobacterial infection. (a–c) The relative expression of selected proinflammatory cytokines (il1b, tnfa, tnfb) in kidneys of unchallenged il10^e46/e46 mutants (n = 10) and WT control fish (n = 10) and in the unsorted kidney cell populations of il10^e46/e46 mutants (n = 10–14) and WT control fish (n = 10–12) at 4 and 8 weeks post a low-dose (1–18 CFU) infection (on the left) as well as in the abdominal organ blocks (including kidney) of unchallenged il10^e46/e46 mutants (n = 12) and WT control fish (n = 12) and at 4 and 9 weeks post a low-dose (2–9 CFU) infection (n = 12 and n = 12, respectively) (on the right) were measured with qPCR. Data are presented as a scatter dot plot and median. Note the different scales of the y axes and the divided y axis in panel a. Gene expressions were normalized to the expression of eef1a1l1. Each dataset was collected from a single experiment. A two-tailed Mann-Whitney was used for the statistical comparison of differences.