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. 2018 Jul 9;8:10349. doi: 10.1038/s41598-018-28581-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Activity-driven LTP causes heterosynaptic depression. (A–D) Synapses with induced LTP. (E–H) Time courses of the changes in the number of AMPARs at each PSD simulated during LTP at PSD1 (E), PSD1 and PSD2 (F), PSD1-PSD3 (G), and PSD1-PSD4 (H). The controls correspond to simulations without the induction of synaptic plasticity (Suppl. Fig. S3) and LTP at single synapses (Suppl. Fig. S4). (I–L) Changes of AMPARs at each PSD from t₁ = 10 s to the end of the simulations caused by LTP at one (I), two (J), three (K) and four synapses (L). The asterisks indicate statistically significant differences (P < 0.05) for paired T-test comparisons with control simulations. (M) The number of vicinal LTP modulated the amplitude of heterosynaptic depression at PSD5. The asterisks indicate statistically significant Tukey post hoc comparisons (P < 0.05).