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. 2018 Jul 9;8:10332. doi: 10.1038/s41598-018-28742-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Trajectory of a chondrocyte in the proliferative zone in vehicle (upper panels) or CNP (lower panels)-treated growth plate organ culture. Pictures in each vertical lane represent the snap shots at indicated time point (hour). Targeted chondrocyte is encircled by yellow dashed ellipse marked by red arrowhead at each time point, which is located on the full trajectory indicated by the same green line, appearing in each set of pictures. The ‘x’ numbered ‘1’ in red character in each snap shot exhibits the start point of the trajectory of the targeted chondrocyte in vehicle or CNP-treated group.