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. 2018 Jul 9;8:10332. doi: 10.1038/s41598-018-28742-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of the proliferation of growth plate chondrocytes using IMARIS. (a) Schema of the method. The maximal cross-section of a targeted chondrocyte was provided at each time point, and the center of the cross-section of the chondrocyte was manually connected for 18 hours using IMARIS. Mitotic division is represented as a branched line, as indicated. (b) A representative series of pictures showing the division of a proliferative chondrocyte. Yellow spheres indicate the centers of the maximal cross-sections of chondrocytes. (c) All proliferative chondrocytes located within a distinct rectangle (depicted by yellow dashed lines) in an imaginary plane were traced, but only the trajectories of dividing chondrocytes are shown. Left, vehicle and right, CNP-treated groups. Colored lines represent trajectories of proliferating chondrocytes divided during the 18-hour observation period. Each branch of the line means mitotic division of a proliferative chondrocyte. The total numbers of branches by all cells traced in vehicle and CNP-treated groups are also indicated.