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. 2018 Jul 9;8:10342. doi: 10.1038/s41598-018-28700-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Structural schematics for the comparison of the molecular organization of influenza virus and virus-like particles (VLPs). (a) Schematic of an influenza virus particle. (b,c,d) Schematics of VLPs containing low, medium, and high amounts of internal components, respectively. Hemagglutinin (HA) is light blue with the membrane in grey. Internal components of VLPs are brick red. For the virus, additional components are viral glycoproteins, which are neuraminidase (NA) (yellow), M2 (light purple), matrix layer (green) with genomic RNP filaments inside with polymerase proteins (yellow) at one end. For clarity only one row of surface glycoproteins is shown. (e) Schematic of HA on the surface of VLPs illustrating neighboring HA molecules that are besides, in front, and behind each other on the surface.