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. 2018 May 17;6(2):199–213. doi: 10.1016/j.jcmgh.2018.05.003

Figure 11.

Figure 11

Diagrammatic representation of mechanisms and signaling pathways by which NGF promotes gastric angiogenesis in aging GECs. The mechanisms and signaling pathways mediating NGF’s actions on aging GECs include activation of PI3 kinase and mTOR signaling, which reverses impaired angiogenesis and cell proliferation, and polymerization of G-actin to F-actin, which increases GEC migration. These actions of NGF on aging GECs are dependent on SRF protein expression. TrkA, tropomyosin receptor kinase A (NGF receptor).