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. 2018 May 17;6(2):199–213. doi: 10.1016/j.jcmgh.2018.05.003

Figure 5.

Figure 5

SRF silencing abolishes NGF-induced angiogenesis and proliferation of aging GECs. SRF was silenced in aging GECs using specific siRNA, and the effect of SRF silencing on in vitro angiogenesis on Matrigel and on GEC proliferation was determined in the presence or absence of NGF. (A) SRF silencing using specific siRNA significantly reduced in vitro angiogenesis in aging GECs (vs cells treated with scrambled [control siRNA]). This reduction in in vitro angiogenesis by SRF siRNA was not affected by treatment with exogenous recombinant rat NGF. Data are means ± SD (N = 6). (B) SRF silencing significantly reduced NGF-induced proliferation aging GECs (vs cells treated with scrambled [control siRNA]). Data are means ± SD (N = 6).