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Pro-SFTPB and DAS as risk markers. (A) Receiver operator characteristic of a smoking based risk model applied to the Pan Canadian Lung Screening cohort and significantly improved performance of the combined base model together with pro-SFTPB; (B) additive performance of Diacetyl spermine, together with pro-SFTPB in a blinded validation study using pre-diagnostic samples from a high risk cohort.
