Table 2. Intra-class correlation coefficient (ICC) calculated for each CANARY exemplar, the VIRO group, and the average of all exemplars.

CANARY exemplar	VUMC cohort (n=45)	Mayo cohort I (n=50)	Mayo cohort II (n=283)
Average ICC (95% CI)	0.828 (0.760–0.895)	0.852 (0.804–0.901)	0.871 (0.843–0.890)
V	0.925 (0.891–0.959)	0.953 (0.930–0.976)	0.922 (0.906–0.936)
I	0.795 (0.710–0.880)	0.871 (0.811–0.931)	0.806 (0.770–0.838)
B	0.910 (0.870–0.951)	0.963 (0.945–0.984)	0.884 (0.861–0.904)
G	0.467 (0.302–0.632)	0.151 (−0.035 to 0.338)	0.707 (0.657–0.753)
Y	0.827 (0.754–0.901)	0.881 (0.826–0.937)	0.834 (0.801–0.861)
O	0.864 (0.804–0.923)	0.965 (0.947–0.982)	0.953 (0.910-0.996)
R	0.977 (0.966–0.988)	0.990 (0.985–0.995)	0.986 (0.983–0.989)
C	0.868 (0.810–0.926)	0.939 (0.909–0.969)	0.878 (0.854–0.899)
P	0.778 (0.687–0.869)	0.866 (0.804–0.928)	0.830 (0.797–0.858)
V-I-R-O	0.865 (0.687–0.869)	0.942 (0.913–0.970)	0.909 (0.890–0.925)

An ICC of 0.8–1 reflects high agreement between users. The average (Avg.) ICC of all exemplars measured as a percentage of the segmented adenocarcinoma volume was calculated for the Vanderbilt University Medical Center (VUMC) and the Mayo Clinic cohorts. ICCs and 95% confidence intervals (CI) are shown.