Table 3. Outcomes from screening before and after stratification by clinical and gene-based approach to assessing risk of lung cancer.

Screening outcome	Before stratification (total), N=10,054	PLCO model* stratification (quintiles 2–4), N=6,032	Gene-based stratification (quintiles 2–4), N=6,171	Gene-based stratification (middle tertile), N=2,970
Relative reduction in lung cancer death (%)	17%	28%	44%	55%†
Absolute lung cancer deaths averted	17	16	29	18
LC deaths averted per 1,000 screened	3.4	5.5	10.2	12.8
NNS# to avert one lung cancer death	294	182	98	84

^#, number needed to screen; *, PLCOm2012 model; ^†, associated with a 21% reduction in all-cause mortality.