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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Nat Rev Endocrinol. 2017 Sep 8;14(2):115–125. doi: 10.1038/nrendo.2017.104

Table 2 |.

Biochemical features of various forms of hyperparathyroidism and FHH

Form of hyperparathyroidism Calcium levels PTH levels Phosphate levels Urinary calcium excretion
Primary hyperparathyroidism Increased Increased or inappropriately normal Low or low-normal FeCA typically >1–2%
Secondary hyperparathyroidism Normal or low Increased Dependent on cause; low or low-normal in vitamin D deficiency or malabsorption; high or high-normal in renal failure Dependent on cause; low in vitamin D deficiency or malabsorption; high in renal calcium leak
Tertiary hyperparathyroidism Increased Increased Variable; dependent on before or after renal transplant Low before renal transplant
Normocalcaemic primary hyperparathyroidism Normal (total & ionized) Increased Normal <350 mg per 24 h29
FHH Increased Increased or inappropriately normal; the majority have normal PTH Normal FeCa typically <1%

FeCa, fractional excretion of calcium; FHH, familial hypocalciuric hypercalcaemia; PTH, parathyroid hormone