. Author manuscript; available in PMC: 2019 Feb 1.

Published in final edited form as: Nat Rev Endocrinol. 2017 Sep 8;14(2):115–125. doi: 10.1038/nrendo.2017.104

Table 4 |.

Response to medication in patients with PHPT^*

Drug	Serum calcium level	Serum PTH level	Urinary calcium excretion	BMD
HCTZ	No change	No change	Decreases	No data
Oestrogen	No change	No change	No change	Increases
Raloxifene	Decreases^**	No change	No change	No data
Alendronate	No change	No change	No change	Increases
Cinacalcet	Decreases	Minimal decrease	No change	No change

We are not recommending the use of these agents in PHPT (the changes described are occasionally based on small numbers of individuals).

^**

At 8 weeks of treatment. HCTZ, hydrochlorothiazide.