Figure 4.

FOXI3 signature genes in prostate and breast cancer metastasis. (A) Publicly available data (Haider et al., 2016) (accession number: GSE74685) downloaded from the series matrix file. Data was median centered and column standardized. Next, tumors were scored for median expression of FOXI3 signature genes depicted in Figure 1. The boxplots show median expression of these genes for tumors at distant sites of metastasis (B) Distant metastasis free survival is shown for breast cancer patient tumors scored for average expression of the FOXI3 signature genes [p-value = 0.00068 and hazard ratio (HR) = 1.77 (1.27–2.47)]. Patient tumors were split into high and low expression groups using the autoselect threshold option on http://kmplot.com/analysis/ (Györffy et al., 2010).