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. 2018 Mar 21;27(3):438–455. doi: 10.1177/0963689718759473

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 9. — Cord blood serum–specific fraction with enhanced α-secretase catalytic activity (αCBSF) reduces β-amyloid plaques in 5XFAD mice. Five-month-old 5XFAD female mice were treated intraperitoneally with αCBSF (n = 5 to 7) and aged blood serum fraction with enhanced α-secretase activity (AgBSF; n = 5 to 6) via osmotic mini pump at 30 μg/mouse/day for 6 wk. (A) Mouse brain sections from each group were stained with 4G8, Congo red, and Thioflavin-S. (B) Percentages of 4G8 positive areas were quantified by ImageJ (1.47v, NIH, USA) analysis for neocortex and hippocampus, showing that αCBSF treatment significantly reduced plaque area compared with AgBSF treatment (t-test for independent samples; *P < 0.05, **P < 0.01).