Table 1.
Year | Phase | Current Status | Area | MSCs | Trial | Intervention | Comparator |
---|---|---|---|---|---|---|---|
2009 | 2 | Active, not recruiting | Europe | Autologous MSCs | Intravenous stem cells after ischemic stroke | Autologous mesenchymal stem cells | No intervention |
2012 | 1 | Recruiting | USA | BM-MSCs | Autologous bone marrow mesenchymal stem cell transplantation for chronic stroke | intracerebral stem cell transplantation | No |
2015 | 1 | Recruiting | China | BM-MSCs | Autologous bone marrow mesenchymal stem cell transplantation for chronic ischemic stroke | intracerebral stem cell transplantation | No |
2015 | 2 | Not yet recruiting | China | UC-MSCs | Umbilical cord–derived mesenchymal stem cells treatment in ischemic stroke | Human umbilical cord mesenchymal stem cells | No intervention |
2012 | 3 | Recruiting | Korea | Autologous MSCs | The stem cell application researches and trials In NeuroloGy-2 (STARTING-2) Study (STARTING-2) | MSC treatment | Standard treatment |
2010 | 2 | Recruiting | Spain | Adipose stem cell | Reparative therapy in acute ischemic stroke with allogenic mesenchymal stem cells from adipose tissue, safety assessment, a randomized, double blind placebo controlled single center pilot clinical trial (AMASCIS-01) | ASC treatment | Placebo: IV fluids |
2011 | 2 | Recruiting | Malaysia | BM-MSCs | Intravenous autologous mesenchymal stem cells transplantation to treat middle cerebral artery infarct | IV infusion of BM-MSC | Standard treatment |
2013 | 1/2 | Not yet recruiting | USA | Allogenic BM-MSCs | Mesenchymal stromal cells for ischemic stroke | IV infusion of BM-MSC | IV normal saline |
2013 | 1 | Unknown status | China | UC-MSCs | Umbilical cord–derived mesenchymal stem cells therapy in hypoxic ischemic encephalopathy | IV infusion of UC-MSC | No |
2011 | 1/2 | Recruiting | China | Autologous BM-MSCs, EPCs | Autologous bone marrow stromal cell and endothelial progenitor cell transplantation in ischemic stroke | IV infusion of BM-MSC | IV normal saline with 5% serum |
2016 | 2/3 | Recruiting | Europe | Adipose stem cell | Regenerative stem cell therapy for stroke in Europe | IV infusion of ASC | IV cell excipients |
Abbreviations: AMETIS, Autologous bone marrow stromal cell and endothelial progenitor cell transplantation in ischemic stroke; MSCs, mesenchymal stem cells; RESTORE, regenerative stem cell therapy for stroke in Europe; SAMCLS, mesenchymal stromal cells for ischemic stroke; UCMSC, umbilical cord mesenchymal stem cells; BMSCs, bone marrow stem cells; EPC, endothelial progenitor cells; ASC, adipose stem cells.