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. 2018 May 14;27(3):456–470. doi: 10.1177/0963689718757408

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 5. — Effect of n-butylidenephthalide (BP) pretreatment on Parkinson’s disease (PD) recovery. (A) Transplantation with pretreated adipose-derived stem cells (ADSCs) significantly improved balancing ability on day 5 compared to that in mice transplanted with untreated ADSCs. (B) Coordination ability in PD mice improved slightly after transplantation with ADSCs or pretreated ADSCs. (C) All groups recovered similarly in terms of total distance traveled and total movement time; no significant improvement was observed compared to that in ADSC transplantation. (D) The total rest time of all groups did not differ significantly; however, slightly better recovery of vertical activity was observed in mice transplanted with BP-pretreated ADSCs. (E) Vertical movement and vertical moving times of mice transplanted with BP-pretreated ADSCs were improved slightly. The results at day 5 were quantified and compared in a bar graph. Error bars represent means ± SDs (N ≥ 6). ***P < 0.001 versus the saline group.

Fig. 5. — Effect of n-butylidenephthalide (BP) pretreatment on Parkinson’s disease (PD) recovery. (A) Transplantation with pretreated adipose-derived stem cells (ADSCs) significantly improved balancing ability on day 5 compared to that in mice transplanted with untreated ADSCs. (B) Coordination ability in PD mice improved slightly after transplantation with ADSCs or pretreated ADSCs. (C) All groups recovered similarly in terms of total distance traveled and total movement time; no significant improvement was observed compared to that in ADSC transplantation. (D) The total rest time of all groups did not differ significantly; however, slightly better recovery of vertical activity was observed in mice transplanted with BP-pretreated ADSCs. (E) Vertical movement and vertical moving times of mice transplanted with BP-pretreated ADSCs were improved slightly. The results at day 5 were quantified and compared in a bar graph. Error bars represent means ± SDs (N ≥ 6). ***P < 0.001 versus the saline group.