Figure 2.

PKM2 silencing in TC cells exhibited a tumor-suppressive function. A. MTT assays revealed that PKM2 knockdown by short interfering RNA significantly suppressed TC cell proliferation. B. Monolayer colony formation assays suggested that PKM2 depletion reduced anchorage-dependent colony formation. C. PKM2 knockdown decreased the cell migration ability of TC cells. D. Cell invasion was significantly inhibited in PKM2-depleted TC cells. E. PKM2 overexpression promoted xenograft formation in nude mice and Ki67 levels in tumors, as assessed by immunohistochemistry.