Figure 1.

In vivo study chronology. Rats received 6-OHDA injection (left “0”), and post-lesion impairment was evaluated by intraperitoneal injection of apomorphine at the end of 2 weeks. One day later, PD rats were divided into 3 groups (Saline group, Lv-MSCs group and Lv-Nurr1-MSCs group). The PD rats in each group were intrastriatal injection of normal saline, GV287-MSCs and GV287-Nurr1-MSCs, respectively. The number of animals in each group was five. 1, 2 and 4 weeks after cell transplantation the rats in each group were examined the behavioral changes. Rats were sacrificed for immunohistochemical, RT-PCR and Western blot studies at the end of 4 weeks post-cell transplantation.