Table 2.
Overall survival and disease-specific survival in univariate analysis and multivariate analysis by Cox proportional hazard model
| Overall survival | Disease-specific survival | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| HR 95% CI | p-value | HR 95% CI | p-value | HR 95% CI | p-value | HR 95% CI | p-value | |
| Age, years | 1.019 (1.002-1.036) | 0.027* | 1.011(0.994-1.029) | 0.201 | 1.012 (0.993-1.032) | 0.223 | 1.004 (0.984-1.024) | 0.723 |
| Gender (male vs female) | 0.963 (0.690-1.344) | 0.825 | 0.909 (0.633-1.393) | 0.755 | 0.881 (0.590-1.316) | 0.536 | 0.870(0.534-1.415) | 0.574 |
| Smoking (yes vs no) | 1.073 (0.716-1.608) | 0.731 | 0.994 (0.611-1.617) | 0.981 | 1.182 (0.734-1.903) | 0.490 | 0.955 (0.525-1.736) | 0.880 |
| Bladder cancer history (yes vs no) | 1.041 (0.730-1.486) | 0.823 | 0.984 (0.675-1.435) | 0.932 | 0.928 (0.597-1.441) | 0.739 | 0.858 (0.536-1.374) | 0.523 |
| Estimated GFR (<60 vs ≧60) | 1.240 (0.865-1.777) | 0.241 | 0.934 (0.638-1.368) | 0.727 | 1.252 (0.809-1.937) | 0.312 | 0.982 (0.614-1.571) | 0.941 |
| Operation method | 0.098 | 0.184 | 0.078 | 0.101 | ||||
| Open | 1 (reference) | - | 1 (reference) | - | 1 (reference) | - | 1 (reference) | - |
| Laparoscopy | 0.632 (0.415-0.963) | 0.033* | 0.705 (0.453-1.096) | 0.121 | 0.558 (0.333-0.937) | 0.027* | 0.615 (0.356-1.063) | 0.082 |
| Segmental resection | 1.028 (0.419-2.524) | 0.952 | 1.459 (0.589-3.616) | 0.414 | 1.141 (0.417-3.121) | 0.798 | 1.723 (0.620-4.792) | 0.297 |
| Multifocality (yes vs no) | 1.741 (1.220-2.486) | 0.002* | 1.319 (0.904-1.926) | 0.151 | 1.847 (1.207-2.826) | 0.005* | 1.337 (0.851-2.101) | 0.207 |
| Grade (high vs low) | 4.243 (2.339-7.696) | < 0.001* | 2.048 (1.023-4.100) | 0.043* | 8.450 (3.103-23.014) | < 0.001* | 2.459 (0.813-7.437) | 0.111 |
| Pathologic T stage (pT2-4 vs pTa/Tis/T1) | 4.188 (2.695-6.507) | < 0.001* | 2.339 (1.378-3.972) | 0.002* | 10.691 (4.949-23.095) | < 0.001* | 5.242 (2.208-12.442) | < 0.001* |
| Pathologic N stage (pN1-3 vs pN0/Nx) | 9.720 (6.234-15.154) | < 0.001* | 6.342 (3.950-10.183) | < 0.001* | 13.236 (8.144-21.510) | < 0.001* | 8.084 (4.804-13.602) | < 0.001* |
| URS biopsy (yes vs no) | 0.946 (0.664-1.348) | 0.760 | 1.069 (0.742-1.541) | 0.720 | 1.085 (0.717-1.644) | 0.699 | 1.260 (0.818-1.941) | 0.294 |
*p<0.05