Table 3.
Metastasis-free survival and intravesical recurrence-free survival in univariate analysis and multivariate analysis by Cox proportional hazard model
| Metastasis-free survival | Intravesical recurrence-free survival | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| HR 95% CI | p-value | HR 95% CI | p-value | HR 95% CI | p-value | HR 95% CI | p-value | |
| Age, years | 1.006 (0.990-1.022) | 0.485 | 0.997 (0.980-1.014) | 0.722 | 1.007 (0.991-1.023) | 0.417 | 1.010 (0.993-1.027) | 0.260 |
| Gender (male vs female) | 0.969 (0.690-1.360) | 0.854 | 0.901 (0.598-1.357) | 0.616 | 0.706 (0.506-0.987) | 0.041* | 0.721 (0.490-1.063) | 0.099 |
| Smoking (yes vs no) | 1.025 (0.676-1.554) | 0.908 | 0.850 (0.509-1.420) | 0.534 | 1.244 (0.837-1.848) | 0.281 | 1.068 (0.672-1.697) | 0.782 |
| Bladder cancer history (yes vs no) | 0.985 (0.683-1.422) | 0.936 | 0.969 (0.660-1.424) | 0.874 | 4.850 (3.440-6.837) | < 0.001* | 5.085 (3.571-7.241) | < 0.001* |
| Estimated GFR (<60 vs ≧60) | 1.153 (0.802-1.658) | 0.442 | 1.037 (0.702-1.532) | 0.853 | 0.998 (0.703-1.417) | 0.993 | 0.898 (0.623-1.293) | 0.562 |
| Operation method | 0.711 | 0.854 | 0.527 | 0.991 | ||||
| Open | 1 (reference) | - | 1 (reference) | - | 1 (reference) | - | 1 (reference) | - |
| Laparoscopy | 0.855 (0.582-1.258) | 0.427 | 1.021 (0.681-1.531) | 0.921 | 0.809 (0.549-1.192) | 0.284 | 1.024 (0.677-1.550) | 0.909 |
| Segmental resection | 0.853 (0.313-2.321) | 0.755 | 1.336 (0.486-3.668) | 0.574 | 1.117 (0.454-2.747) | 0.809 | 1.041 (0.413-2.624) | 0.932 |
| Multifocality (yes vs no) | 1.952 (1.366-2.789) | < 0.001* | 1.474 (1.014-2.143) | 0.042* | 1.132 (0.765-1.676) | 0.536 | 0.885 (0.587-1.334) | 0.559 |
| Grade (high vs low) | 4.613 (2.419-8.796) | < 0.001* | 1.986 (0.961-4.105) | 0.064 | 0.981 (0.670-1.437) | 0.923 | 1.015 (0.643-1.601) | 0.950 |
| Pathologic T stage (pT2-4 vs pTa/Tis/T1) | 5.183 (3.188-8.426) | < 0.001* | 2.983 (1.701-5.230) | < 0.001* | 1.042 (0.743-1.462) | 0.810 | 1.178 (0.784-1.770) | 0.430 |
| Pathologic N stage (pN1-3 vs pN0/Nx) | 8.895 (5.859-13.504) | < 0.001* | 5.786 (3.696-9.058) | < 0.001* | 0.977 (0.428-2.231) | 0.977 | 0.930 (0.396-2.184) | 0.867 |
| URS biopsy (yes vs no) | 0.963 (0.679-1.367) | 0.834 | 1.046 (0.727-1.505) | 0.808 | 1.093 (0.776-1.539) | 0.611 | 1.113 (0.776-1.596) | 0.560 |
*p<0.05