Table 5.

Cox models measured incidence densities and hazard ratio of intravesical recurrence outcome

	N	Total person-year	Case	per 1000 person-year Incident rate	Crude HR (95% CI)	p-value	adjust HR (95% CI)	p-value
Main Effect
URS- (Ref.)	2,634	6,243	392 (14.88%)	62.79	1 (Ref.)		1 (Ref.)
URS+	3,079	7,261	515 (16.73%)	70.92	1.129 (0.99 - 1.29)	0.069	1.136 (1.00 - 1.30)	0.059
Baseline Patient Demographic Characteristics
Gender
Female (Ref.)	3,241	7,798	464 (14.32%)	59.50	1 (Ref.)		1 (Ref.)
Male	2,472	5,707	443 (17.92%)	77.63	1.285 (1.13 - 1.46)	<0.001*	1.293 (1.13 - 1.48)	<0.001*
Age Categories
<65 yr(Ref.)	2,044	5,028	332 (16.24%)	66.03	1 (Ref.)		1 (Ref.)
65-74 yr	2,094	4,994	324 (15.47%)	64.87	0.978 (0.84 - 1.14)	0.771	0.994 (0.85 - 1.16)	0.935
>74yr	1,575	3,482	251 (15.94%)	72.09	1.067 (0.91 - 1.26)	0.440	1.087 (0.92 - 1.29)	0.334
CCI score Categories
0 (Ref.)	613	1,467	95 (15.50%)	64.75	1 (Ref.)		1 (Ref.)
1	462	1,105	68 (14.72%)	61.53	0.947 (0.69 - 1.29)	0.731	0.932 (0.68 - 1.28)	0.661
2+	4,638	10,932	744 (16.04%)	68.06	1.048 (0.85 - 1.30)	0.667	0.917 (0.73 - 1.15)	0.454
Hypertension
No (Ref.)	2,743	6,560	437 (15.93%)	66.61	1 (Ref.)		1 (Ref.)
Yes	2,970	6,944	470 (15.82%)	67.68	1.009 (0.89 - 1.15)	0.887	1.011 (0.88 - 1.16)	0.870
Hyperlipidemia
No (Ref.)	4,509	10,591	731 (16.21%)	69.02	1 (Ref.)		1 (Ref.)
Yes	1,204	2,913	176 (14.62%)	60.42	0.884 (0.75 - 1.04)	0.141	0.883 (0.74 - 1.05)	0.155
DM
No (Ref.)	4,399	10,447	686 (15.59%)	65.66	1 (Ref.)		1 (Ref.)
Yes	1,314	3,057	221 (16.82%)	72.29	1.098 (0.94 - 1.28)	0.227	1.152 (0.98 - 1.35)	0.085
ESRD
No (Ref.)	4,562	10,876	704 (15.43%)	64.73	1 (Ref.)		1 (Ref.)
Yes	1,151	2,628	203 (17.64%)	77.23	1.186 (1.01 - 1.39)	0.033*	1.221 (1.04 - 1.44)	0.017*

Crude HR relative hazard ratio, Adjusted HR adjusted hazard ratio controlling for age, gender, CCI score, Hypertension, Hyperlipidemia, diabetes and ESRD

*p<0.05