Table 2.
Differentially gene expression in the TGFβ-signaling pathway
| Gene name | Tumor mean | Tumor SD | Normal mean | Normal SD | Fold change | (95% CI) | Adjusted P value | % FC < 0.67 | % FC > 1.5 |
|---|---|---|---|---|---|---|---|---|---|
| BMP5 | 3.93 | 0.30 | 22.50 | 1.61 | 0.17 | (0.14, 0.21) | 3.54E−39 | 84.3 | 3.7 |
| BMP6 | 4.29 | 0.31 | 17.05 | 1.06 | 0.25 | (0.21, 0.30) | 2.55E−35 | 77.4 | 4.1 |
| IFNG | 0.78 | 0.12 | 2.48 | 0.31 | 0.32 | (0.22, 0.45) | 2.10E−09 | 47.0 | 3.7 |
| BMP2 | 20.73 | 1.04 | 64.78 | 2.92 | 0.32 | (0.28, 0.36) | 2.85E−41 | 81.1 | 4.1 |
| CDKN2B | 24.21 | 1.23 | 74.65 | 3.43 | 0.32 | (0.29, 0.37) | 1.57E−41 | 80.2 | 6.0 |
| GDF7 | 1.48 | 0.14 | 3.63 | 0.30 | 0.41 | (0.32, 0.51) | 9.55E−13 | 55.3 | 7.8 |
| AMHR2 | 0.16 | 0.05 | 0.38 | 0.12 | 0.43 | (0.24, 0.78) | 7.72E−03 | 18.4 | 1.8 |
| LEFTY2 | 0.68 | 0.14 | 1.57 | 0.32 | 0.43 | (0.31, 0.60) | 2.11E−06 | 34.1 | 7.4 |
| ACVR1C | 7.52 | 0.45 | 14.84 | 0.89 | 0.51 | (0.43, 0.60) | 2.99E−13 | 64.1 | 10.6 |
| LEFTY1 | 32.87 | 3.41 | 64.73 | 5.42 | 0.51 | (0.40, 0.65) | 1.84E−07 | 61.3 | 15.7 |
| FST | 1.87 | 0.20 | 3.18 | 0.36 | 0.59 | (0.45, 0.76) | 1.21E−04 | 37.8 | 6.9 |
| GDF6 | 0.86 | 0.12 | 1.46 | 0.22 | 0.59 | (0.42, 0.83) | 3.37E−03 | 30.4 | 6.5 |
| THBS1 | 585.51 | 23.55 | 881.12 | 35.29 | 0.66 | (0.61, 0.72) | 1.76E−17 | 50.7 | 10.1 |
| MAPK3 | 62.34 | 2.09 | 92.73 | 3.04 | 0.67 | (0.62, 0.73) | 4.62E−18 | 50.7 | 6.9 |
| SMAD1 | 27.03 | 0.89 | 36.99 | 1.22 | 0.73 | (0.67, 0.80) | 1.75E−11 | 46.1 | 9.2 |
| CHRD | 6.54 | 0.44 | 8.90 | 0.59 | 0.73 | (0.62, 0.87) | 4.89E−04 | 41.9 | 15.7 |
| SMAD4 | 89.84 | 2.47 | 119.48 | 3.27 | 0.75 | (0.71, 0.80) | 3.59E−16 | 37.8 | 5.5 |
| SMAD7 | 31.79 | 1.14 | 40.98 | 1.46 | 0.78 | (0.70, 0.85) | 1.05E−06 | 41.0 | 15.7 |
| SMAD9 | 26.96 | 1.61 | 34.30 | 1.95 | 0.79 | (0.68, 0.91) | 1.62E−03 | 49.3 | 19.8 |
| ZFYVE9 | 50.10 | 1.37 | 62.66 | 1.71 | 0.80 | (0.74, 0.86) | 2.93E−08 | 38.7 | 7.4 |
| ID3 | 31.30 | 1.51 | 38.32 | 1.79 | 0.82 | (0.73, 0.91) | 6.80E−04 | 43.3 | 18.4 |
| SMAD2 | 161.37 | 4.37 | 194.68 | 5.24 | 0.83 | (0.78, 0.88) | 4.56E−09 | 33.6 | 8.8 |
| ACVR1B | 94.45 | 2.49 | 112.99 | 2.93 | 0.84 | (0.78, 0.90) | 1.88E−06 | 35.9 | 10.1 |
| NBL1 | 181.16 | 5.41 | 213.28 | 6.34 | 0.85 | (0.80, 0.91) | 4.56E−06 | 33.6 | 10.6 |
| SMAD3 | 106.05 | 2.59 | 124.63 | 3.00 | 0.85 | (0.80, 0.91) | 2.27E−06 | 28.1 | 9.2 |
| PPP2CB | 55.72 | 1.63 | 65.30 | 1.88 | 0.85 | (0.79, 0.92) | 8.37E−05 | 35.5 | 12.4 |
| EP300 | 293.90 | 3.99 | 339.29 | 4.67 | 0.87 | (0.84, 0.90) | 8.90E−14 | 16.6 | 3.2 |
| RPS6KB2 | 35.48 | 0.90 | 40.51 | 1.06 | 0.88 | (0.82, 0.93) | 1.16E−04 | 28.6 | 14.3 |
| ACVR2A | 39.04 | 1.43 | 43.73 | 1.60 | 0.89 | (0.82, 0.98) | 1.70E−02 | 28.6 | 16.6 |
| RBX1 | 20.82 | 0.70 | 23.31 | 0.83 | 0.89 | (0.82, 0.97) | 1.35E−02 | 29.0 | 17.5 |
| BMP8B | 21.66 | 0.75 | 24.25 | 0.87 | 0.89 | (0.81, 0.98) | 2.30E−02 | 35.0 | 20.7 |
| NODAL | 2.36 | 0.20 | 2.63 | 0.23 | 0.90 | (0.71, 1.14) | 4.10E−01 | 35.0 | 11.5 |
| INHBE | 0.80 | 0.10 | 0.86 | 0.12 | 0.93 | (0.67, 1.30) | 7.08E−01 | 28.1 | 5.5 |
| TNF | 1.95 | 0.20 | 2.04 | 0.25 | 0.96 | (0.72, 1.27) | 7.71E−01 | 26.3 | 10.1 |
| CREBBP | 264.23 | 3.97 | 273.44 | 4.17 | 0.97 | (0.93, 1.00) | 7.19E−02 | 8.3 | 5.5 |
| ROCK1 | 143.22 | 3.87 | 148.19 | 4.03 | 0.97 | (0.91, 1.02) | 2.61E−01 | 19.4 | 15.2 |
| DCN | 73.70 | 4.09 | 75.88 | 3.96 | 0.97 | (0.84, 1.12) | 7.08E−01 | 38.2 | 28.1 |
| GDF5 | 0.19 | 0.06 | 0.20 | 0.06 | 0.99 | (0.58, 1.70) | 9.72E−01 | 14.7 | 3.2 |
| ZFYVE16 | 102.11 | 2.67 | 101.55 | 2.72 | 1.01 | (0.95, 1.07) | 8.66E−01 | 15.2 | 19.4 |
| MAPK1 | 183.50 | 3.04 | 179.79 | 3.01 | 1.02 | (0.98, 1.07) | 3.91E−01 | 6.5 | 10.1 |
| TGFB1 | 41.60 | 1.76 | 39.64 | 1.64 | 1.05 | (0.94, 1.17) | 3.99E−01 | 33.2 | 29.0 |
| SMURF1 | 112.79 | 2.32 | 106.62 | 2.22 | 1.06 | (1.00, 1.12) | 4.85E−02 | 11.1 | 20.7 |
| PPP2R1B | 81.03 | 1.94 | 76.22 | 1.88 | 1.06 | (1.00, 1.13) | 5.57E−02 | 11.1 | 16.6 |
| SP1 | 287.39 | 4.77 | 266.86 | 4.51 | 1.08 | (1.03, 1.12) | 4.71E−04 | 5.5 | 10.6 |
| ID2 | 26.59 | 1.11 | 24.40 | 1.03 | 1.09 | (0.98, 1.22) | 1.41E−01 | 25.8 | 31.8 |
| TGFBR2 | 197.09 | 4.95 | 178.93 | 4.49 | 1.10 | (1.03, 1.18) | 7.47E−03 | 18.9 | 28.6 |
| PPP2R1A | 142.03 | 2.87 | 127.10 | 2.65 | 1.12 | (1.07, 1.17) | 1.18E−05 | 8.3 | 18.9 |
| BMPR1A | 20.81 | 0.79 | 18.58 | 0.74 | 1.12 | (1.01, 1.24) | 3.21E−02 | 21.2 | 26.7 |
| SKP1 | 91.51 | 2.16 | 81.23 | 1.97 | 1.13 | (1.06, 1.19) | 1.28E−04 | 12.0 | 20.3 |
| PPP2CA | 101.95 | 2.74 | 90.28 | 2.47 | 1.13 | (1.06, 1.20) | 1.85E−04 | 10.6 | 21.7 |
| BMPR1B | 3.21 | 0.39 | 2.83 | 0.35 | 1.13 | (0.85, 1.51) | 4.18E−01 | 27.6 | 11.5 |
| TGFB3 | 16.83 | 0.94 | 14.40 | 0.78 | 1.17 | (1.01, 1.35) | 4.71E−02 | 31.3 | 31.3 |
| ACVR1 | 33.10 | 0.98 | 28.22 | 0.88 | 1.17 | (1.08, 1.28) | 4.18E−04 | 15.7 | 36.4 |
| ID4 | 13.08 | 0.76 | 11.09 | 0.67 | 1.18 | (1.00, 1.39) | 6.14E−02 | 31.8 | 32.7 |
| ID1 | 53.99 | 3.59 | 45.77 | 2.69 | 1.18 | (1.00, 1.39) | 5.57E−02 | 37.3 | 33.2 |
| PITX2 | 11.58 | 1.16 | 9.64 | 0.99 | 1.20 | (0.90, 1.59) | 2.34E−01 | 23.0 | 26.7 |
| RPS6KB1 | 49.77 | 1.39 | 41.07 | 1.18 | 1.21 | (1.13, 1.30) | 4.70E−07 | 8.8 | 27.6 |
| BMP8A | 5.36 | 0.39 | 4.37 | 0.33 | 1.23 | (1.03, 1.46) | 2.56E−02 | 28.6 | 25.3 |
| E2F4 | 71.86 | 1.84 | 58.20 | 1.54 | 1.23 | (1.17, 1.31) | 1.97E−11 | 10.6 | 32.3 |
| ACVR2B | 14.96 | 0.59 | 12.09 | 0.52 | 1.24 | (1.12, 1.36) | 3.44E−05 | 20.3 | 36.9 |
| BMPR2 | 219.08 | 5.39 | 176.91 | 4.38 | 1.24 | (1.17, 1.32) | 1.08E−10 | 10.6 | 30.4 |
| LTBP1 | 77.75 | 2.98 | 61.80 | 2.43 | 1.26 | (1.13, 1.40) | 7.76E−05 | 23.0 | 36.9 |
| SMAD6 | 21.19 | 0.93 | 16.42 | 0.78 | 1.29 | (1.15, 1.44) | 2.26E−05 | 18.4 | 39.6 |
| SMAD5 | 124.87 | 3.71 | 94.20 | 2.84 | 1.33 | (1.24, 1.41) | 3.30E−15 | 8.8 | 35.5 |
| SMURF2 | 51.22 | 1.61 | 38.21 | 1.27 | 1.34 | (1.24, 1.45) | 1.04E−11 | 11.1 | 39.6 |
| RHOA | 282.98 | 5.14 | 209.50 | 3.91 | 1.35 | (1.29, 1.42) | 4.34E−26 | 3.7 | 39.6 |
| CUL1 | 74.71 | 1.95 | 53.22 | 1.45 | 1.40 | (1.31, 1.50) | 9.04E−19 | 6.5 | 40.1 |
| E2F5 | 46.80 | 1.65 | 30.87 | 1.18 | 1.52 | (1.38, 1.67) | 3.20E−15 | 11.5 | 48.4 |
| TGFBR1 | 106.44 | 3.40 | 70.13 | 2.27 | 1.52 | (1.40, 1.65) | 3.31E−18 | 6.5 | 50.7 |
| TGIF1 | 81.12 | 2.46 | 50.35 | 1.61 | 1.61 | (1.49, 1.75) | 7.21E−24 | 8.3 | 55.3 |
| AMH | 5.92 | 0.63 | 3.39 | 0.36 | 1.74 | (1.37, 2.22) | 1.63E−05 | 27.6 | 28.1 |
| BAMBI | 9.61 | 0.80 | 5.20 | 0.46 | 1.85 | (1.48, 2.30) | 2.72E−07 | 25.8 | 32.3 |
| INHBB | 5.87 | 0.55 | 3.08 | 0.30 | 1.91 | (1.52, 2.39) | 1.43E−07 | 22.1 | 30.4 |
| TGFB2 | 9.23 | 0.60 | 4.52 | 0.34 | 2.04 | (1.71, 2.44) | 2.96E−13 | 16.1 | 37.8 |
| BMP4 | 48.63 | 2.94 | 22.37 | 1.33 | 2.17 | (1.88, 2.52) | 6.72E−20 | 13.8 | 53.0 |
| TFDP1 | 119.20 | 3.35 | 54.04 | 1.61 | 2.21 | (2.03, 2.39) | 1.55E−47 | 3.2 | 76.5 |
| RBL1 | 53.52 | 1.98 | 23.32 | 0.93 | 2.30 | (2.08, 2.54) | 4.37E−39 | 7.8 | 69.6 |
| TGIF2 | 58.87 | 2.18 | 22.72 | 0.91 | 2.59 | (2.33, 2.88) | 5.45E−42 | 6.5 | 71.0 |
| MYC | 181.11 | 8.63 | 49.00 | 2.42 | 3.70 | (3.28, 4.17) | 2.33E−53 | 6.0 | 82.0 |
| BMP7 | 37.91 | 3.18 | 9.09 | 0.80 | 4.17 | (3.34, 5.20) | 4.84E−27 | 16.6 | 51.2 |
| INHBA | 125.48 | 8.60 | 13.43 | 1.08 | 9.34 | (7.67, 11.39) | 5.94E−56 | 4.6 | 75.1 |