Figure 2.

(a) In vivo imaging of unconjugated CdTe MPA QDs (2.5 mg/kg body wt.) in mouse paw edema model showing evenly distributed fluorescence in the whole body at 0 h (left); in vivo imaging of mouse shows no significant fluorescence specifically localized anywhere in the body at 24 h (right). (b) In vivo imaging of QD-Celecoxib conjugates (2.5 mg/kg body wt.) at 3 h of posttreatment in mouse paw edema model showing the clear localization of QD-Celecoxib conjugates in inflamed tissue of paw edema, and the arrow indicates may be some deposition in the brain region also in dorsal view (left); ventral view of same mouse showing localization of QD-Celecoxib conjugates near the heart region other than in the paw edema tissue (right). (c) In vivo imaging of mice treated with QD-Celecoxib conjugates (2.5 mg/kg body wt.) at different time intervals: (A) 6 hrs, (B) 12 h, and (C) 24 h postinjection of QD-Celecoxib conjugates through tail vein. An increase in fluorescence intensity near the urinary bladder (circled area) with increasing time up to 12 h and a later decrease at 24 h can be observed that. Arrows in (A) and (B) are thought to be the deposition of QD-Celecoxib conjugates in the brain region, which cleared after 12 h.