Figure 3.

Suppression of YAP impaired protective effects of propofol in HT-22 cell apoptosis induced by H/R. (a) Reduced YAP expression by YAP shRNA in HT-22 cells detected by Western blots. ^aP < 0.001 versus shRNA NC. (b) The effect of downregulation of YAP on cell apoptosis induced by H/R with or without propofol (15 μmol/l) pretreatment in HT-22 cells (conducted 48 hr post shRNA treatment). The results are from three independent experiments. (^aDifferences were significant when compared with “control,” P < 0.05. ^bDifferences were significant when compared with “H/R,” P < 0.05. ^cDifferences were not significant when compared with “H/R,” P > 0.05.)