Reference | Imaging | Histopathology | Light chain restriction | Bone marrow | Systemic amyloidosis | Lab tests | Molecular testing |
---|---|---|---|---|---|---|---|
(1) Lehman et al. [1] | MRI- isointense on T1 and hyperintense on T2 | Intracerebral and vascular amyloid deposition, CD 20+ B cells and plasmacytoid cell infiltrates, CD138+ plasma cells | Kappa | Normal | NR | SPEP and UPEP- normal, CBC- normal |
ND |
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(2) Pace et al. [2] | MRI- isointense on T1, hypointense on T2 | Intracerebral and vascular amyloid deposition, CD 20+ B cells and plasmacytoid cell infiltrates, CD138+ plasma cells | Kappa | Normal | Ruled out by serum amyloid P component scan | SPEP- normal, normal serum free kappa, free lambda and kappa: lambda ratio | ND |
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(3) Tu et al. [3] | NR | Amyloid deposition, CD20 + B cell infiltrates | Kappa | NR | NR | NR | Trisomy 3 positive, Negative for MALT1 and IgH translocation |
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(4) Tu et al. [3] | NR | Amyloid deposition, cyclin D1-, CD20 + B-cell infiltrates | Kappa | NR | NR | NR | Trisomy 3 positive, Negative for MALT1 and IgH translocation |
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(5) Our case | MRI-T2 hyperintense | Intraparenchymal and perivascular amyloid deposition (AL subtype). CD20+, CD3-, CD5-, BCL1-, CD23- plasmacytoid lymphocytes and CD138+ plasma cells | Lambda | Normal | Ruled out by abdominal fat biopsy | Normal serum free kappa, free lambda and kappa: lambda ratio | MYD88 L265P mutation analysis was negative |
NR: not reported; ND: not done.