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. 2018 Jun 12;2018:2109352. doi: 10.1155/2018/2109352

Figure 3.

Figure 3

CGRP reduced ADAM17 expression and activation of EGFR and ERK1/2 in vascular smooth muscle cells treated with Ang II. After being pretreated with 10 nmol/l CGRP or/and 10 nmol/l CGRP 8–37 for 30 minutes, vascular smooth muscle cells were treated with 100 nmol/l Ang II for 24 hours. (a) ADAM17 protein level, n = 4 independent experiments. (b) ADAM17 mRNA level, n = 3 independent experiments. (c) EGFR activity, n = 4 independent experiments. (d) ERK1/2 activity, n = 3 independent experiments. Ang II represents angiotensin II. ∗ P < 0.05 versus control, ∗∗ P < 0.01 versus control, # P < 0.05 versus Ang II, and & P < 0.05 versus Ang II + CGRP.