Table 2.
The correlation between clinical variables in patients with rheumatic disease and the proportion of myeloid derived suppressor cells, as well as their subsets.
| Correlation Analysis | MDSC | M-MDSC | G-MDSC | ||||
|---|---|---|---|---|---|---|---|
| r | p | r | p | r | p | ||
| Rheumatoid Arthritis | Age (years) | -0.255 | 0.165 | -0.239 | 0.195 | -0.145 | 0.436 |
| Disease Duration (years) | 0.007 | 0.972 | 0.052 | 0.781 | -0.093 | 0.621 | |
| ESR (mm/h) | 0.265 | 0.150 | 0.322 | 0.077 | 0.081 | 0.665 | |
| CRP (mg/L) | 0.379 | 0.036∗ | 0.594 | 0.000∗∗∗ | -0.095 | 0.611 | |
| Total Joint Pain (scores) | 0.529 | 0.002∗∗ | 0.766 | 0.000∗∗∗ | 0.142 | 0.446 | |
| Swollen Joint Counts (n) | 0.305 | 0.095 | 0.371 | 0.040∗ | 0.164 | 0.379 | |
| HAQ (scores) | -0.003 | 0.987 | 0.160 | 0.390 | 0.066 | 0.722 | |
| DAS28 (scores) | 0.481 | 0.006∗∗ | 0.749 | 0.000∗∗∗ | 0.047 | 0.801 | |
| IgM RF (IU/ml) | 0.140 | 0.453 | 0.272 | 0.139 | 0.015 | 0.936 | |
| ACPA (U/ml) | 0.475 | 0.007∗∗ | 0.668 | 0.000∗∗∗ | 0.000 | 1.000 | |
|
| |||||||
| Ankylosing Spondylitis | Age (years) | -0.154 | 0.506 | -0.211 | 0.359 | -0.142 | 0.538 |
| Disease Duration (years) | -0.217 | 0.345 | -0.214 | 0.352 | -0.330 | 0.144 | |
| ESR (mm/h) | 0.087 | 0.709 | -0.145 | 0.529 | 0.046 | 0.844 | |
| CRP (mg/L) | 0.494 | 0.023∗ | 0.801 | 0.000∗∗∗ | 0.043 | 0.854 | |
| Total Joint Pain (scores) | 0.707 | 0.000∗∗∗ | 0.799 | 0.000∗∗∗ | -0.065 | 0.780 | |
| ASDAS (scores) | 0.596 | 0.004∗∗ | 0.908 | 0.000∗∗∗ | 0.042 | 0.858 | |
| BASFI (scores) | 0.228 | 0.320 | 0.251 | 0.273 | -0.151 | 0.512 | |
|
| |||||||
| Osteoarthritis | Age (years) | 0.051 | 0.863 | 0.055 | 0.852 | -0.256 | 0.376 |
| Disease Duration (years) | 0.073 | 0.805 | -0.068 | 0.817 | -0.276 | 0.34 | |
| ESR (mm/h) | 0.037 | 0.899 | 0.037$ | 0.900 | -0.165$ | 0.573 | |
| CRP (mg/L) | 0.877 | 0.000∗∗∗ | 0.746$ | 0.002∗∗ | 0.408$ | 0.148 | |
| Total Joint Pain (scores) | 0.813 | 0.000∗∗∗ | 0.844 | 0.000∗∗∗ | 0.387 | 0.171 | |
| Swollen Joint Counts (n) | 0.330 | 0.250 | 0.590 | 0.026∗ | 0.186 | 0.525 | |
|
| |||||||
| Systemic Lupus Erythematosus With Arthritis | Age (years) | 0.061$ | 0.858 | -0.460 | 0.154 | 0.234$ | 0.489 |
| Disease Duration (years) | 0.133 | 0.697 | 0.078 | 0.820 | 0.357 | 0.281 | |
| ESR (mm/h) | 0.173 | 0.611 | 0.378 | 0.252 | -0.342 | 0.304 | |
| CRP (mg/L) | 0.555 | 0.077 | 0.855 | 0.001∗∗ | -0.309 | 0.355 | |
| Total Joint Pain (scores) | 0.761$ | 0.007∗∗ | 0.934 | 0.000∗∗∗ | 0.101$ | 0.768 | |
| Swollen Joint Counts (n) | 0.551 | 0.079 | 0.918 | 0.000∗∗∗ | -0.217 | 0.522 | |
| SLEDAI (scores) | 0.139$ | 0.683 | 0.161 | 0.636 | 0.607$ | 0.048∗ | |
| ANA (U/ml) | -0.184$ | 0.589 | 0.000 | 1.000 | 0.335$ | 0.315 | |
| Anti-dsDNA (U/ml) | 0.203$ | 0.549 | 0.182 | 0.593 | 0.622$ | 0.041∗ | |
| C3 (g/L) | 0.229$ | 0.497 | -0.328 | 0.352 | -0.112$ | 0.743 | |
|
| |||||||
| Systemic Lupus Erythematosus Without Arthritis | Age (years) | 0.059 | 0.847 | -0.039 | 0.900 | 0.033 | 0.915 |
| Disease Duration (years) | -0.155 | 0.613 | -0.077 | 0.801 | 0.109 | 0.722 | |
| ESR (mm/h) | 0.252 | 0.405 | 0.163 | 0.596 | -0.072 | 0.816 | |
| CRP (mg/L) | 0.171 | 0.577 | 0.489 | 0.090 | -0.149 | 0.628 | |
| SLEDAI (scores) | 0.038$ | 0.901 | -0.196$ | 0.522 | 0.054 | 0.861 | |
| ANA (U/ml) | 0.219$ | 0.471 | -0.067$ | 0.828 | 0.096 | 0.754 | |
| Anti-dsDNA (U/ml) | -0.315$ | 0.295 | -0.244$ | 0.421 | -0.077 | 0.802 | |
| C3 (g/L) | -0.433$ | 0.139 | -0.580$ | 0.038∗ | -0.432 | 0.141 | |
|
| |||||||
| Gout | Age (years) | -0.770 | 0.015∗ | -0.683 | 0.042∗ | -0.169$ | 0.665 |
| Disease Duration (years) | -0.218 | 0.574 | -0.200 | 0.606 | 0.051$ | 0.897 | |
| ESR (mm/h) | 0.151 | 0.699 | 0.433 | 0.244 | 0.235$ | 0.543 | |
| CRP (mg/L) | 0.762 | 0.017∗ | 0.883 | 0.002∗∗ | 0.833 | 0.005∗∗ | |
| Total Joint Pain (scores) | 0.795 | 0.010∗ | 0.911 | 0.001∗∗ | 0.868$ | 0.002∗∗ | |
| Swollen Joint Counts (n) | 0.712 | 0.031∗ | 0.878 | 0.002∗∗ | 0.833 | 0.005∗∗ | |
| SUA (μmol/L) | -0.151 | 0.699 | -0.183 | 0.637 | 0.082$ | 0.833 | |
|
| |||||||
| Hyperuricemia | Age (years) | 0.077$ | 0.833 | -0.123 | 0.736 | 0.330$ | 0.351 |
| Disease Duration (years) | 0.091 | 0.803 | 0.018 | 0.960 | 0.049 | 0.894 | |
| ESR (mm/h) | -0.395$ | 0.259 | -0.326 | 0.358 | -0.170$ | 0.640 | |
| CRP (mg/L) | 0.430 | 0.214 | 0.159 | 0.661 | 0.543 | 0.105 | |
| SUA (μmol/L) | -0.231$ | 0.522 | -0.275 | 0.441 | 0.213$ | 0.554 | |
Note: ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; HAQ, health assessment questionnaire; DAS28, disease activity score in 28 joints; RF, rheumatoid factor; ACPA, anti-citrullinated protein antibody; ASDAS, ankylosing spondylitis disease activity score; BASFI, bath ankylosing spondylitis functional index; SLEDAI, systemic lupus erythematosus disease activity index; ANA, antinuclear antibody; Anti-dsDNA, anti-double stranded DNA antibody; C3, complement C3; SUA, serum uric acid; MDSC, myeloid derived suppressor cell; M-MDSC, monocytic MDSC; G-MDSC, granulocytic MDSC; Total Joint Pain was assessed on a visual analog scale (0-10 cm); r, all showed by Spearman's rank correlation coefficient, except when marked with $ (Pearson's correlation coefficient);. ∗p<0.05, ∗∗p<0.01, and ∗∗∗p<0.001.