Table 4.

Body weight of and fasting blood glucose and plasma insulin levels, HOMA-IR and glucose and insulin AUC after iv bolus injection of dextrose in 12–14 year-old baboon offspring

Treatment	Age (yrs)	Body wt (gm)	Glucose (mg/dl)	Insulin (μIU/ml)	Glucose AUC (mg/dl)	Insulin AUC (μIU/ml)	HOMA-IR
Untreated	12.5 ± 0.8	15.5 ± 0.6	72 ± 2	10.5 ± 4.3	515 ± 21	253 ± 80	1.9 ± 0.8
Letrozole	13.0 ± 1.1	16.5 ± 0.3	74 ± 4	9.4 ± 3.2	498 ± 22	198 ± 57	1.8 ± 0.6

Values are expressed as means ± SE after an iv bolus of dextrose to female offspring from baboons untreated (n = 4) or treated on days 100–165/175 of gestation (term = 184 days) with letrozole (115 μg/kg body weight/day via maternal sc injection, n = 4)