Table 2. Summary of histopathologic findings for 6 Guiana dolphins recovered from Ilha Grande Bay, Rio de Janeiro, Brazil, 2017*.

No.	Tissue	Histopathologic findings
1†	Lung	Marked, multifocal chronic bronchointerstitial pneumonia and proliferative pleuritis with sclerosis, type II pneumocyte hyperplasia, syncytia/multinucleated cells, rare INCIBs, calcified nematode debris and edema; multifocal tunica media hypertrophy/hyperplasia
	Mammary gland	Mild to moderate, multifocal, chronic lymphoplasmacytic and histiocytic mastitis with acinar ectasia, inspissated secretion, scattered necrosis, ceroid pigment and moderate INCIBs in epithelium
	Heart	Mild, focal, subacute fibrinous pericarditis; mild, multifocal myocardial fibrosis
	Kidney	Mild, multifocal, chronic membranous glomerulonephritis with glomerulocysts, tubular proteinosis, protein casts, and scattered tubuloepithelial necrosis
	Pulmonary lymph node	Mild, multifocal, chronic nodular eosinophilic and necrotizing lymphadenitis with fibrosis and hemosiderosis; diffuse lymphoid depletion
	Mediastinal lymph node	Mild, multifocal, chronic eosinophilic lymphadenitis; diffuse congestion
	Spleen	Diffuse congestion and multifocal, acute capsular hemorrhage; extramedullary hematopoiesis
	Adrenal	Mild, multifocal, acute corticomedullary hemorrhage
	Aorta	Mild, segmental, chronic proliferative endarteritis
	Liver	Moderate, multifocal, chronic bile duct adenomatous hyperplasia
	Uterus	Moderate, multifocal, chronic arteriosclerosis and arterial elastosis
	Glandular stomach	Mild, diffuse mucosal hyperplasia; multifocal arterial tunica media hypertrophy/hyperplasia
2‡	Lung	Mild, multifocal, acute interstitial pneumonia associated with marked alveolar edema, hemorrhage and alveolar histiocytosis, syncytia/multinucleated cells and keratin spicules
	Kidney	Mild, multifocal, acute tubular degeneration and necrosis; mild, multifocal, acute tubular proteinosis and protein casts; marked, focal, acute perirenal hemorrhage
	Pulmonary lymph node	Moderate, diffuse cortical and paracortical lymphoid depletion with scattered lymphocytolysis
	Prescapular lymph node	Diffuse congestion with focal acute hemorrhage and erythrophagocytosis; sinus vascularization
	Spleen	Moderate, diffuse, lymphoid depletion with sinus histiocytosis; extramedullary hematopoiesis
	Heart	Moderate, multifocal, acute subendocardial and epicardial hemorrhage
	Adrenal	Marked, multifocal, acute cortico-medullary hemorrhagic necrosis
	Esophagus	Focal acute hemorrhage in serosa
	Urinary bladder	Edema and focal acute hemorrhage in serosa
	Penis	Urethral luminal hemorrhage with single cell epithelial necrosis/apoptosis
	Cerebrum, cerebellum	Diffuse leptomeningeal congestion and perivascular edema in neuroparenchyma
10§	Lung	Mild to moderate, multifocal, chronic suppurative bronchopneumonia with adult nematodes (Halocercus sp.); multifocal alveolar, bronchiolar and bronchial mineralization
	Keratinized stomach	Mild, focal, chronic proliferative gastritis
	Skeletal muscle	Scattered acute hyaline myocyte degeneration and necrosis
11	Ascending aorta	Marked, segmental, chronic fibrosing and proliferative endarteritis with chondroid metaplasia and calcification; moderate, focal, chronic granulomatous periarteritis; mild, multifocal intimal fibroelastosis
	Aortic (semilunar) valve	Mild, multifocal, chronic intimal/endocardial fibroelastosis
12¶	Keratinized stomach	Mild, focal, chronic mononuclear gastritis
13#	Lung	Marked, multifocal, chronic suppurative to pyogranulomatous bronchopneumonia with bronchial/olar sclerosis, adult and larval nematodes (Halocercus sp.) and moderate, multifocal, chronic proliferative and fibrosing (villous) pleuritis; marked, multifocal, chronic tunica media arterial hypertrophy/hyperplasia with stenosis
	Skin	Mild, multifocal, chronic irregular epidermal hyperplasia
	Pyloric stomach	Moderate, focal, chronic granulomatous gastritis with numerous trematode ova (compatible with Pholeter gastrophilus)

*INCIBs, intranuclear and intracytoplasmic inclusion bodies; no., animal no.
†No significant lesions were observed for large intestine, thyroid, skin, trachea, cerebrum, cerebellum, spinal cord, or skeletal muscle.
‡No significant lesions were observed for keratinized and pyloric stomach, tongue, aorta, small intestine, pancreas, or trachea.
§Unable to observe lesions in liver, spleen, kidney, testicle, trachea, small and large intestine, skin, periaortic lymph node, cerebrum, or cerebellum because of advanced autolysis of animal.
¶Unable to observe lesions in ovary, skin, liver, skeletal muscle, heart, kidney, spleen, large intestine, bladder, lymph node, or adrenal gland because of advanced autolysis of animal.
#Unable to observe lesions in small intestine, liver, skeletal muscle, adrenal gland, bladder, kidney, or heart because of advanced autolysis of animal.