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. Author manuscript; available in PMC: 2019 May 30.
Published in final edited form as: J Am Chem Soc. 2018 May 17;140(21):6545–6549. doi: 10.1021/jacs.8b03509

Table 2.

The Scope of Aryl Iodides for Enantioselective Arylation of Cyclopropanecarboxylic Acida,b

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a

Conditions 1 (0.2 mmol), 2 (2.0 equiv), Pd(OAc)2 (10 mol%), L1 (20 mol%), Ag2CO3 (1.5 equiv), Na2CO3 (1.5 equiv), HFIP (0.25 mL), 80 °C, air, 16 h.

b

Isolated yields.

c

Conditions 2a (0.2 mmol), 1 (2.0 equiv), Pd(OAc)2 (10 mol%), L1 (20 mol%), Ag2CO3 (1.0 equiv), Na2CO3 (1.5 equiv), HFIP (0.25 mL), 80 °C, air, 16 h.

d

Using AgOAc (3.0 equiv) instead of Ag2CO3 (1.5 equiv), NaHCO3 (1.5 equiv) instead of Na2CO3 (1.5 equiv).

e

Using 2 (1.5 equiv).