Table 2.
Conditions 1 (0.2 mmol), 2 (2.0 equiv), Pd(OAc)2 (10 mol%), L1 (20 mol%), Ag2CO3 (1.5 equiv), Na2CO3 (1.5 equiv), HFIP (0.25 mL), 80 °C, air, 16 h.
Isolated yields.
Conditions 2a (0.2 mmol), 1 (2.0 equiv), Pd(OAc)2 (10 mol%), L1 (20 mol%), Ag2CO3 (1.0 equiv), Na2CO3 (1.5 equiv), HFIP (0.25 mL), 80 °C, air, 16 h.
Using AgOAc (3.0 equiv) instead of Ag2CO3 (1.5 equiv), NaHCO3 (1.5 equiv) instead of Na2CO3 (1.5 equiv).
Using 2 (1.5 equiv).