. Author manuscript; available in PMC: 2019 May 30.

Published in final edited form as: J Am Chem Soc. 2018 May 17;140(21):6545–6549. doi: 10.1021/jacs.8b03509

Table 3.

Enantioselective Arylation of Substituted Cyclopropanecarboxylic Acid^a,^b

Conditions 4 (0.2 mmol), 2a (2.0 equiv), Pd(OAc)₂ (10 mol%), L1 (20 mol%), Ag₂CO₃ (1.5 equiv), Na₂CO₃ (1.5 equiv), HFIP (0.25 mL), 80 °C, air, 16 h.

Isolated yields.

60 °C.

Using AgOAc (3.0 equiv) instead of Ag₂CO₃ (1.5 equiv), NaHCO₃ (1.5 equiv) instead of Na₂CO₃ (1.5 equiv), 60 °C.