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. Author manuscript; available in PMC: 2019 May 30.
Published in final edited form as: J Am Chem Soc. 2018 May 17;140(21):6545–6549. doi: 10.1021/jacs.8b03509

Table 4.

Enantioselective Arylation of 2-aminoisobutyric Acida,b

graphic file with name nihms974038f5.jpg
a

Conditions: 1 (0.1 mmol), 7 (2.5 equiv), Pd(OAc)2 (10 mol%), L1 (20 mol%), AgOAc (3.0 equiv), NaHCO3 (1.5 equiv), HFIP, 80 °C, air, 24 h.

b

Isolated yields.

c

Isolated as the corresponding methyl ester.