Table 1.
Baseline Characteristics of Those Who Developed Corneal Perforation or Underwent Therapeutic Penetrating Keratoplasty
| TPK (n = 122) | No TPK (n = 118) | OR (95% CI) | P Valuea | |
|---|---|---|---|---|
| Sex, No. (%)b | ||||
| Male | 70 (57.9) | 65 (55.5) | 0.94 (0.56–1.57) | .82 |
| Female | 51 (42.1) | 52 (44.4) | ||
| Age, median (IQR), y | 53.5 (42–63) | 51.5 (45–60) | 1.01 (0.99–1.03) | .31 |
| Occupation, No. (%) | ||||
| Agriculture | 64 (52.5) | 77 (65.3) | 0.59 (0.35–0.99) | .045c |
| Nonagricultured | 58 (47.5) | 41 (34.7) | ||
| Trauma/injury, No. (%) | 53 (43.4) | 63 (53.4) | 0.98 (0.77–1.24) | .88 |
| Vegetative matter/wood | 36 (29.5) | 38 (32.2) | ||
| Metal/othere | 27 (22.1) | 37 (31.4) | ||
| Unknown object | 2 (1.6) | 4 (3.4) | ||
| Affected eye, No. (%) | ||||
| Right | 80 (65.5) | 59 (50.0) | 0.80 (0.53–1.21) | .29 |
| Visual acuity, logMAR, median (IQR) | 1.7 (1.70–1.80) | 1.66 (1.22–1.80) | 1.17 (1.08–1.27) | <.001c |
| Infiltrate/Scar, median (IQR), mmf | 6.07 (5.00–6.94) | 5.00 (4.90–5.92) | 1.51 (1.26–1.81) | <.001c |
| Hypopyon, No. (%), mm | ||||
| No | 22 (18.3) | 43 (37.7) | 2.70 (1.52–4.82) | .001c |
| <0.5 | 19 (15.8) | 20 (17.5) | ||
| ≥0.5 | 79 (65.8) | 51 (44.7) | ||
| % of Depth, No. (%) | ||||
| >0–33 | 18 (15.0) | 40 (33.9) | 2.25 (1.56–3.24) | <.001c |
| >33–67 | 46 (38.3) | 56 (47.5) | ||
| >67–100 | 55 (45.8) | 22 (18.6) | ||
| Epithelial defect, median (IQR), mmf | 5.02 (3.88–6.08) | 4.36 (3.07–5.23) | 1.23 (1.06–1.42) | .005c |
| Organism | ||||
| Fusarium | 42 | 30 | 1.05 (0.83–1.34) | .69 |
| Aspergillus | 31 | 32 | ||
| Other | 31 | 30 | ||
| Duration of symptoms, median (IQR), d | 10.00 (7.00–15.00) | 9.50 (5.00–15.25) | 0.99 (0.97–1.02) | .56 |
| Systemic disease, No. (%)g | 9 (7.4) | 17 (14.4) | 0.47 (0.20–1.10) | .09 |
Abbreviations: IQR, interquartile range; OR, odds ratio; TPK, therapeutic penetrating keratoplasty.
Univariate analysis to determine whether baseline characteristic predicts the development of corneal perforation or the need for therapeutic penetrating keratoplasty.
Two patients were missing values for sex.
Statistically significant difference in univariate analysis and added to multivariate logistic regression model.
Includes unemployed and retired.
Includes dust, battery acid, ash, cement, fingernail, stick, cow or buffalo tail, goat horn, and insect.
Geometric mean of the longest diameter and longest perpendicular to that diameter in millimeters.
Includes diabetes mellitus, asthma, and hypertension.