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. 2018 Jul 5;14:1779–1786. doi: 10.2147/NDT.S162562

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© 2018 Wu et al. This work is published and licensed by Dove Medical Press Limited

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D1R interacts with Shp-2 in the striatal neurons.

Notes: Striatal proteins were coimmunoprecipitated with anti-D1R and anti-Shp-2 antibodies (A and B). Representative immunoblots showing D1R and Shp-2 interactions in striatal neurons as detected by coimmunoprecipitation. No precipitating antibody, an irrelevant IgG was used in L2, L3, respectively. The D1R antibody (L4A) or Shp-2 antibody (L4B) was used in L4 for normal rats and L5 for LID rats, respectively. No striatal proteins and antibodies were used in L1.

Abbreviations: IP, immunoprecipitation; D1R, D1 dopamine receptor; L1, lane 1; L2, lane 2; L3, lane 3; L4, lane 4; L5, lane 5; LID, levodopa-induced dyskinesia.