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. 2018 Jul 5;14:1779–1786. doi: 10.2147/NDT.S162562

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© 2018 Wu et al. This work is published and licensed by Dove Medical Press Limited

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Molecular events underlying LID involving D1R/Shp-2 complex and its downstream signaling factors, such as ERK1/2 and mTOR.

Notes: The bands represent immunoblot images detected by antibodies against p-Shp-2 (A), p-ERK (B) and p-mTOR (C). Proteins were analyzed from the sham group (1), l-DOPA group (2), SCH23390 + l-DOPA group (3), SKF38393 group (4). Repeated administration of l-DOPA increased the level of p-Shp-2, p-ERK1/2 and p-mTOR. SKF38393 increased the levels similarly. Conversely, SCH23390 plus L-DOPA prevented the increase. Data are presented as mean ± SD. *p < 0.05, versus sham group; ^#p < 0.05, versus l-DOPA group. Data are statistically analyzed by one-way ANOVA test.

Abbreviations: ANOVA, analysis of variance; D1R, D1 dopamine receptor; ERK1/2, extracellular signal-regulated kinases 1 and 2; l-DOPA, l-3,4-dihydroxyphenylalanine; LID, levodopa-induced dyskinesia.