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. 2018 Jul 4;13:3867–3881. doi: 10.2147/IJN.S161423

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© 2018 Zhou et al. This work is published and licensed by Dove Medical Press Limited

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Tenogenic differentiation of hASCs on microscaled (A and B) and nanoscaled (C and D) aligned topographical surface on day 3 (A and C) and on day 7 (B and D), respectively. qPCR analysis showed significantly enhanced gene expression of tenogenic markers when cells were cultured on microscaled and nanoscaled aligned topographical surface. *p<0.05; **p<0.01; ***p<0.001.

Abbreviations: BGN, biglycan; COL 1, type I collagen; COL 3, type III collagen; COL 6, type VI collagen; DCN, decorin; FMOD, fibromodulin; hASCs, human adipose-derived stem cells; qPCR, quantitative PCR; SCX, scleraxis; TNC, tenascin-C; TNMD, tenomodulin.