Table S1.

Mathematical models used to describe drug dissolution curves

Equation	Model	Description
Qt = In Q0 + KIt	First order	Qt: amount of drug dissolved in time t, Q0: initial amount of drug in the solution, t: time, Q∞: amount of drug dissolved in time ∞, and K1, K0, KC, KH, and KK are the rate constants for first order, zero order, Hixson–Crowell, Higuchi matrix, and Korsmeyer–Peppas, respectively
Qt = Q0 + K0t	Zero order
Q1/30 – Q1/3t = KCt	Hixson–Crowell
Qt = KHt1/2	Higuchi matrix
Qt/Q∞ = KKtn	Korsmeyer–Peppas
Release profiles comparison
$f_t=\frac{{\displaystyle {\sum }_{j=1}^n\left|R_j-T_j\right|}}{{\displaystyle {\sum }_{j=1}^n{R}_j}}\times 100$	Dissimilarity factor (f1)	n: sampling number, Rj and Tj: percentage dissolved of the reference and test products at each time point j
$f_2=50\times \log \left\{{\left[1+(1/n){\displaystyle \sum _{j=1}^n{\left|R_j-T_j\right|}^2}\right]}^{-0.5}\times 100\right\}$	Similarity factor (f2)