Table 1.
Clinical presentation of urosepsis
| Documented urinary tract Infection or pyuria |
|---|
| Appearance |
| • Fever (temperature >38.5°C) |
| • Hypothermia (temperature <36°C) |
| • Tachypnea |
| • Altered mental status |
| Inflammatory response |
| • Leukocytosis (WBC count >11000/μL) |
| • Leukopenia (WBC count <4000/μL) |
| • Normal WBC count with greater than 10% immature forms |
| Hemodynamic dysfunction |
| • Hypotension (SBP <90 mmHg, MAP <70 mmHg) |
| • Tachycardia (heart rate >90/min) |
| Organ dysfunction |
| • Hypoxemia (Pao2/Fio2 <300) |
| • Oliguria (urine output <0.5 mL/kg/hr for ≥ 2 hours despite sufficient fluid resuscitation) |
| • Elevated creatinine (increase >0.5 mg/dL from baseline) |
| • Disordered coagulation (INR >1.5) |
| Tissue malperfusion |
| • Elevated lactate (>2 mmol/L) |
| • Prolonged capillary refill time |
| • Skin mottling |
Note: Data from Wagenlehner et al.13
Abbreviations: MAP, mean arterial pressure; WBC, white blood cells; INR, international normalized ratio; aPTT, activated partial thromboplastin time; SBP, systolic blood pressure.