Table 3.
Cause-specific hazard ratios for spontaneous delivery according to FADS gene variants in mother-offspring pairs from the GUSTO cohort.1
| All ethnic subgroups2 | Chinese | Malay | Indian | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SNPs | Minor allele | Mm | mm | Mm | mm | Mm | mm | Mm + mm3 | |
| Mothers | n=897 | n=516 | n=231 | n=150 | |||||
| rs1745464 (FADS1) | G | 0.89 (0.73, 1.09) | 0.82 (0.62, 1.08) | 0.82 (0.63, 1.06) | 0.70 (0.50, 0.99)* | 1.08 (0.77, 1.51) | 1.06 (0.55, 2.05) | 1.06 (0.79, 1.43) | |
| rs2727270 (FADS2) | A | 1.02 (0.83, 1.26) | 1.14 (0.88, 1.49) | 1.09 (0.83, 1.43) | 1.44 (1.04, 1.99)* | 0.93 (0.64, 1.35) | 0.78 (0.48, 1.26) | 0.89 (0.60, 1.32) | |
| rs174593 (FADS2) | G | 1.16 (0.96, 1.41) | 0.97 (0.61, 1.55) | 0.99 (0.76, 1.30) | 1.17 (0.55, 2.48) | 1.36 (0.97, 1.91) | 0.97 (0.54, 1.76) | 1.18 (0.90, 1.55) | |
| rs498793 (FADS2) | A | 0.94 (0.76, 1.17) | 1.48 (0.90, 2.45) | 0.81 (0.58, 1.12) | 1.85 (0.59, 5.79) | 1.13 (0.79, 1.61) | 3.42 (1.64, 7.11)** | 0.87 (0.68, 1.11) | |
| rs17156506 (FADS2) | A | 1.17 (0.92, 1.50) | 1.49 (0.66, 3.34) | 1.31 (0.93, 1.84) | 1.97 (0.73, 5.33) | 1.04 (0.71, 1.52) | 1.12 (0.28, 4.56) | 1.04 (0.66, 1.64) | |
| rs174450 (FADS3) | C | 1.11 (0.90, 1.37) | 1.51 (1.18, 1.95)** | 1.06 (0.82, 1.38) | 1.44 (1.03, 2.03)* | 0.95 (0.58, 1.53) | 1.46 (0.90, 2.39) | 1.48 (1.08, 2.02)* | |
| rs1000778 (FADS3) | A | 1.04 (0.86, 1.25) | 1.35 (1.03, 1.78)* | 0.93 (0.73, 1.20) | 1.46 (0.98, 2.18) | 1.09 (0.77, 1.54) | 1.25 (0.77, 2.04) | 1.38 (1.05, 1.83)* | |
| rs174455 (FADS3) | G | 1.08 (0.88, 1.33) | 1.42 (1.11, 1.82)** | 1.04 (0.80, 1.35) | 1.33 (0.95, 1.85) | 0.97 (0.63, 1.49) | 1.40 (0.89, 2.2) | 1.46 (1.08, 1.99)* | |
| Offspring | n=1100 | n=626 | n=277 | n=197 | |||||
| rs1745464 (FADS1) | G | 0.94 (0.78, 1.14) | 0.77 (0.59, 1.01) | 0.96 (0.76, 1.22) | 0.66 (0.47, 0.93)* | 0.94 (0.69, 1.29) | 1.04 (0.53, 2.06) | 1.05 (0.80, 1.39) | |
| rs2727270 (FADS2) | A | 1.06 (0.87, 1.29) | 1.10 (0.85, 1.42) | 1.28 (1.00, 1.65) | 1.20 (0.85, 1.68) | 0.80 (0.56, 1.14) | 0.95 (0.63, 1.42) | 0.78 (0.50, 1.23) | |
| rs174593 (FADS2) | G | 1.07 (0.89, 1.28) | 1.33 (0.91, 1.93) | 1.13 (0.88, 1.44) | 1.87 (0.92, 3.79) | 0.93 (0.68, 1.29) | 1.16 (0.73, 1.86) | 1.08 (0.85, 1.37) | |
| rs498793 (FADS2) | A | 1.04 (0.85, 1.27) | 1.07 (0.68, 1.69) | 1.03 (0.77, 1.39) | 1.61 (0.60, 4.34) | 1.08 (0.77, 1.50) | 1.26 (0.61, 2.58) | 0.94 (0.76, 1.16) | |
| rs17156506 (FADS2) | A | 1.10 (0.88, 1.37) | 2.41 (0.89, 6.48) | 1.18 (0.89, 1.58) | 3.89 (0.54, 27.77) | 0.94 (0.64, 1.38) | 1.85 (0.59, 5.81) | 1.11 (0.73, 1.68) | |
| rs174450 (FADS3) | C | 1.22 (1.01, 1.48)* | 1.51 (1.20, 1.89)*** | 1.27 (0.99, 1.61) | 1.80 (1.31, 2.48)*** | 1.29 (0.86, 1.94) | 1.45 (0.96, 2.18) | 0.94 (0.74, 1.20) | |
| rs1000778 (FADS3) | A | 1.15 (0.97, 1.36) | 1.28 (0.98, 1.68) | 1.10 (0.88, 1.37) | 1.64 (1.10, 2.44)* | 1.20 (0.87, 1.66) | 1.12 (0.70, 1.77) | 1.13 (0.89, 1.43) | |
| rs174455 (FADS3) | G | 1.17 (0.97, 1.42) | 1.40 (1.11, 1.77)** | 1.20 (0.95, 1.52) | 1.65 (1.19, 2.30)** | 1.29 (0.87, 1.92) | 1.39 (0.93, 2.09) | 0.94 (0.74, 1.19) | |
1
Values are cause-specific hazard ratios (95% CI) for the incidence of birth by spontaneous labor for heterozygotes Mm and minor allele homozygotes mm (as compared to major allele homozygotes MM). Estimates were assessed by cause-specific proportional hazards model. p-values: *<0.05, **<0.01, ***<0.001.
2
Models in all ethnic subgroups were adjusted for ethnicity.
3
In Indians, homozygotes for the minor allele were too few and were therefore combined with the heterozygote group.
4
rs174546 is in negative linkage disequilibrium with the other SNPs.