Table 4.
Mean differences in birth length and weight according to FADS gene variants in mother-offspring pairs from the GUSTO cohort.1
| Birth length | Birth weight | ||||
|---|---|---|---|---|---|
| SNPs | Minor allele | Unadjusted2, cm | Gestational age-specific z-score | Unadjusted2, g | Gestational age-specific z-score |
| Mothers | n=502 | n=502 | |||
| rs1745463 (FADS1) | G | 0.33 (0.03, 0.62)* | 0.10 (-0.04, 0.23) | 47 (-10, 104) | 0.06 (-0.08, 0.19) |
| rs2727270 (FADS2) | A | -0.34 (-0.63, -0.05)* | -0.11 (-0.25, 0.02) | -42 (-98, 14) | -0.06 (-0.19, 0.07) |
| rs174593 (FADS2) | G | 0.02 (-0.34, 0.37) | 0.01 (-0.15, 0.17) | -3 (-71, 66) | -0.02 (-0.18, 0.14) |
| rs498793 (FADS2) | A | 0.24 (-0.14, 0.62) | 0.15 (-0.02, 0.33) | 73 (0, 147) | 0.24 (0.07, 0.41)** |
| rs17156506 (FADS2) | A | -0.52 (-0.99, -0.05)* | -0.30 (-0.52, -0.08)** | -58 (-149, 33) | -0.16 (-0.38, 0.05) |
| rs174450 (FADS3) | C | -0.35 (-0.63, -0.07)* | 0.00 (-0.13, 0.13) | -66 (-120, -12)* | 0.00 (-0.13, 0.12) |
| rs1000778 (FADS3) | A | -0.17 (-0.45, 0.11) | 0.05 (-0.08, 0.18) | -45 (-99, 9) | -0.01 (-0.13, 0.12) |
| rs174455 (FADS3) | G | -0.37 (-0.63, -0.10)** | -0.03 (-0.15, 0.10) | -75 (-127, -23)** | -0.05 (-0.17, 0.07) |
| Offspring | n=601 | n=601 | |||
| rs1745463 (FADS1) | G | 0.52 (0.22, 0.81)*** | 0.15 (0.02, 0.28)* | 66 (9, 122)* | 0.05 (-0.08, 0.18) |
| rs2727270 (FADS2) | A | -0.28 (-0.57, 0.00) | -0.05 (-0.17, 0.08) | -32 (-86, 22) | 0.02 (-0.10, 0.15) |
| rs174593 (FADS2) | G | -0.31 (-0.62, 0.01) | -0.16 (-0.30, -0.02)* | -34 (-94, 27) | -0.09 (-0.23, 0.05) |
| rs498793 (FADS2) | A | 0.13 (-0.23, 0.49) | 0.03 (-0.13, 0.19) | 63 (-5, 131) | 0.14 (-0.02, 0.29) |
| rs17156506 (FADS2) | A | -0.34 (-0.80, 0.12) | -0.20 (-0.41, 0.00) | -33 (-121, 55) | -0.09 (-0.30, 0.11) |
| rs174450 (FADS3) | C | -0.48 (-0.73, -0.23)*** | -0.13 (-0.25, -0.02)* | -63 (-111, -15)* | -0.05 (-0.16, 0.06) |
| rs1000778 (FADS3) | A | -0.33 (-0.60, -0.06)* | -0.03 (-0.15, 0.09) | -57 (-109, -5)* | -0.04 (-0.16, 0.08) |
| rs174455 (FADS3) | G | -0.43 (-0.68, -0.17)** | -0.10 (-0.21, 0.02) | -77 (-125, -28)** | -0.09 (-0.20, 0.02) |
1
Values are mean differences (95% CI) in birth length and weight per copy of the minor allele among participants who experienced a spontaneous labor. Estimates were assessed by linear regression. p-values: *<0.05, **<0.01, ***<0.001.
2
Models were adjusted for ethnicity.
3
rs174546 is in negative linkage disequilibrium with the other SNPs.