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. Author manuscript; available in PMC: 2018 Oct 11.
Published in final edited form as: Nature. 2018 Apr 11;556(7701):332–338. doi: 10.1038/s41586-018-0023-4

Extended Data Figure 9. Peripherally applied cytokines induce immune memory in the brain.

Extended Data Figure 9

a, Experimental design. b, Cytokine responses in the brain, four weeks after peripheral cytokine application (n=17,5,5,21,8,8,15 animals). Note that TNF-α dose-dependently enhances (low dose) or decreases (high dose) certain cytokines. Similar to high dose TNF-α, certain cytokines are also reduced by peripheral application of IL-10 four weeks earlier. c, Cytokine responses in the periphery are unaffected (n=8,21,9,5,10 animals). Data are means±s.e.m. */**/*** P<0.05/0.01/0.001 for one-way ANOVA with Tukey correction.