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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Clin Cancer Res. 2018 Feb 2;24(15):3681–3691. doi: 10.1158/1078-0432.CCR-17-2259

Figure 5. The proposed mechanism of how BQ323636.1 could induce tamoxifen resistance in breast cancer.

Figure 5

When BQ323636.1 interacts with NCOR2, this prevents other co-repressor proteins such as TBLR1 and HDAC3 from binding to NCOR2, which renders NCOR2 unable to form functional repressor complexes to suppress ER-mediated gene transcription.