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. 2018 Jul 6;11:3919–3929. doi: 10.2147/OTT.S166149

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© 2018 Yu et al. This work is published and licensed by Dove Medical Press Limited

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Integrated network analysis outlining the biochemical interconnections between metabolites in the reprogrammed metabolic pathways of SCLCC.

Note: Values in the circle were the fold changes of metabolites levels, protein or gene expression compared to the control cells.

Abbreviations: AMP, adenosine monophosphate; APRT, adenine phosphoribosyltransferase; ATP, adenosine triphosphate; CoA, coenzyme A; CPT, carnitine palmitoyltransferase; F6P, fructose 6-phosphate; FBP, fructose bisphosphate; GTP, guanosine-5′-triphosphate; HPRT, hypoxanthine–guanine phosphoribosyltransferase; IMP, inosine monophosphate; OAA, oxaloacetic acid; PEP, phosphoenolpyruvate; PFK, phosphofructokinase; PKM, pyruvate kinase M; SCLCC, small cell lung cancer cells; TCA, trichloroacetic acid.