Table 1. Optimization Studies Using 1a as Substrate.
entrya | C4F9I (equiv) | solvent (mL) | yield (%)b | E/Z (ratio)c |
---|---|---|---|---|
1 | 1.5 | MeCN (2) | 63 | 4:1 |
2 | 2.0 | MeCN (2) | 67 | 5:1 |
3 | 5.0 | MeCN (2) | 69 | 9:1 |
4 | 10.0 | MeCN (2) | 69 | 12:1 |
5 | 5.0 | MeCN (1) | 66 | 8:1 |
Reactions were conducted with 1a (0.3 mmol).
Yields provided represent isolated yields.
Selectivity was determined by 1H NMR spectroscopy.