Table 1.
Mean values of the relevant CBC indices and Hb subtypes among the studied population, carrying one of the first nine mostly common HBB pathogenic variants reported in the Khorasan province. The total number of studied individuals is indicated in parenthesis under mutations’ names. Hb subtypes are reported as a percent of the total Hb amount of the individuals’ PB sample. dL: deciliter; fL: femtoliter; gm: grams; mcL: microliter; p: p-value; pg: picogram.
| Indices/Mutation Unit/(Number) | IVS-I-5 (535) | IVS-II-1 (143) | Codons 8/9 (61) | Codon 44 (58) | Codon 15 (45) | LosAngeles (37) | Codon 5 (35) | IVS-I-110 (32) | −88 (28) | p |
|---|---|---|---|---|---|---|---|---|---|---|
| RBC × 106 cells/mcL ±SD | 5.87 ± 0.48 | 5.84 ±0.79 | 5.85 ±0.78 | 5.67 ±0.65 | 5.75 ±0.83 | 5.89 ±0.86 | 5.54 ±0.75 | 5.46 ±0.86 | 5.57 ±1.23 | 0.30 |
| Hb gm/dL ±SD | 13.23 ±1.98 | 12.62 ±5.14 | 11.86 ±1.60 | 11.84 ±1.4 | 11.68 ±1.60 | 11.65 ±2.08 | 11.82 ±1.83 | 11.59 ±1.58 | 11.47 ±2.54 | 0.66 |
| MCV fL ±SD | 68.33 ±6.21* | 64.59 ±8.71* | 66.88 ±6.83* | 68.62 ±6.97* | 67.13 ±5.18 | 62.99 ±5.27 | 69.12 ±7.05* | 68.61 ±5.95* | 65.00 ±12.98 | 0.03* |
| MCH pg/cell ±SD | 22.46 ±2.11 | 20.87 ±3.16 | 20.41 ±2.69 | 21.16 ±2.95 | 20.79 ±2.54 | 19.77 ±2.16 | 21.42 ± 2.67 | 21.58 ±3.61 | 20.07 ±4.20 | 0.47 |
| HbA2 percent ±SD | 4.56 ±1.59 | 4.72 ±1.42* | 4.48 ±1.30* | 3.80 ±1.35* | 4.11 ±1.10 | 4.64 ±0.95 | 3.80 ±0.86 | 4.32 ±1.18 | 4.19 ±1.08* | 0.003* |
| HbF percent ±SD | 3.16 ±4.61 | 1.62 ±8.22 | 3.08 ±14.62 | 3.03 ±13.45 | 2.28 ±5.20 | 0.26 ±0.29 | 2.37 ±3.62 | 0.74 ±1.61 | 1.64 ±2.64 | 0.81‡ |
*
Significant difference at α=0.05.
‡
The Kruskal Wallis test was used for the comparison while other parameters were compared between groups using the ANOVA test.