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. 2018 Jul 10;7:e34961. doi: 10.7554/eLife.34961

Figure 2. Cell surface stabilities of HLA-Bw6 allotypes are allele-dependent.

Figure 2.

Left column: Representative cell surface stability measurements of Bw6 epitopes on freshly isolated lymphocytes derived from Bw4/Bw6 heterozygous donors expressing HLA-B*08:01, HLA-B*35:01 or HLA-B*07:02 as the Bw6 allotype. Right column: Bw6 half-lives from Figure 2—source data 1 are grouped by Bw6 allele. Each data point represents data derived from an individual donor, with the open data points representing donors shown in the left panel. Mean half-life values are shown for each donor, measured using freshly isolated cells from at least two independent blood collections for each donor. The number of replicate measurements for each donor and standard errors of the mean are shown in Figure 2—source data 1. Statistical significance is based on one-way ANOVA analysis. p *<0.05, **<0.01, ***<0.001, and ****<0.0001 This figure has one source data table.

Figure 2—source data 1. HLA-Bw6 stability on lymphocytes.
Calculated HLA-Bw6 half-lives on lymphocytes from donors with relevant HLA-B genotypes indicated. The complete HLA class I genotypes of the donors are specified in Figure 1—source data 1. Mean half-life values are shown along with standard errors of mean half-life values (SEM) and the number of measurements (N; from separate blood collections) used for calculating the mean values.
elife-34961-fig2-data1.docx (23.4KB, docx)
DOI: 10.7554/eLife.34961.011