Table II. Compared Mean Scores Between Groups for the Big Five Factors and Sense of Humor.

Results of the pairwise comparisons of the scores between groups are summarized by showing p-values resulting from a bilateral and heteroscedastic Student test. Bolded significance (p-value < 0.05) has been confirmed by a Wilcoxon-Mann-Whitney test. The rightmost column shows a pairwise test between one RASopathy and the combination of the other three RASopathies or controls compared with the combination of all four RASopathies.

Big Five Factors		CS		NF1		NS		vs Controls		vs Other RAS
		Tdf	p	Tdf	p	Tdf	p	Tdf	p	Tdf	p
Agreeableness	CFC	T41=1.98	0.055	T37=0.15	0.885	T35=0.57	0.570	T73=2.23	0.029	T132=2.00	0.274
	CS			T40=1.49	0.144	T38=1.34	0.188	T76=0.02	0.982	T132=2.13	0.035
	NF1					T34=0.35	0.730	T72=1.62	0.109	T132=0.67	0.503
	NS							T70=1.53	0.130	T132=0.17	0.865
	Controls									T132=2.26	0.025
Extraversion	CFC	T40=1.30	0.199	T36=0.17	0.870	T34=0.23	0.819	T72=3.68	<10−3	T131=0.73	0.469
	CS			T40=0.93	0.359	T38=0.91	0.366	T76=2.61	0.011	T131=1.37	0.172
	NF1					T34=0.05	0.960	T72=2.85	0.006	T131=0.35	0.725
	NS							T70=2.93	0.005	T131=0.28	0.783
	Controls									T131=4.58	<10−4
Conscientiousness	CFC	T37=0.12	0.907	T33=0.14	0.890	T31=2.09	0.045	T69=3.27	0.001	T128=0.66	0.510
	CS			T40=0.24	0.809	T38=2.16	0.037	T76=3.67	<10−3	T128=0.62	0.535
	NF1					T34=1.85	0.072	T72=2.74	0.007	T128=0.77	0.442
	NS							T70=1.20	0.233	T128=2.51	0.013
	Controls									T128=4.29	<10−4
Intellectual openness	CFC	T37=1.00	0.325	T32=0.99	0.331	T31=2.49	0.018	T69=4.66	<10−4	T127=1.73	0.085
	CS			T39=0.25	0.802	T38=1.67	0.104	T76=4.47	<10−4	T127=0.43	0.665
	NF1					T33=1.01	0.319	T71=2.62	0.011	T127=0.08	0.937
	NS							T70=2.12	0.037	T127=1.98	0.049
	Controls									T127=6.10	<10−7
Neuroticism	CFC	T41=0.12	0.908	T37=0.61	0.546	T35=0.22	0.825	T73=0.89	0.377	T132=0.39	0.700
	CS			T40=0.60	0.553	T38=0.15	0.884	T76=1.04	0.302	T132=0.30	0.764
	NF1					T34=0.41	0.524	T72=0.08	0.934	T132=0.63	0.531
	NS							T70=0.64	0.683	T132=0.02	0.984
	Controls									T132=0.98	0.326
Sense of Humor	CFC	T39=1.08	0.288	T33=0.01	0.994	T33=0.42	0.677	T71=1.85	0.068	T128=0.28	0.779
	CS			T38=1.01	0.320	T38=1.46	0.152	T76=1.06	0.293	T128=1.69	0.093
	NF1					T32=0.39	0.696	T70=1.71	0.093	T128=0.27	0.789
	NS							T70=2.13	0.037	T128=0.90	0.370
	Controls									T128=2.91	0.004