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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: J Immunol. 2018 Jun 1;201(2):533–547. doi: 10.4049/jimmunol.1800250

Figure 7. PCV2 Cap and gC1qR interaction activates PI3K/Akt1 and p38 MAPK signalings to regulate miR-23a, miR-23b, miR-29a and miR-29b expression.

Figure 7

(A) PCV2 infected gC1qR+/+ and gC1qR−/− PAMs at 1 MOI for 24 h, the expression of miR-23a, miR-23b, miR-29a, and miR-29b were measured. (B-D) The specific siRNAs of Akt1 (B), p38 MAPK (C), and ERK1 (D) were transfected into wild-type PAMs for 24 h, then the cells were infected with 1 MOI of PCV2 for another 24 h. The expression of miR-23a, miR-23b, miR-29a, and miR-29b were analyzed. *P < 0.05, **P < 0.01 versus PCV2-infected gC1qR+/+ PAMs for same detected miRNA (A). #P < 0.05, ##P < 0.01 versus PCV2-infected negative control siRNA transfected cells for same miRNA detected (B - D).