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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: J Immunol. 2018 Jun 8;201(2):393–405. doi: 10.4049/jimmunol.1701588

Figure 4. TLR 7- mediated lupus nephritis occurs in an interferon-independent manner.

Figure 4

10 week- old NZM2328 and INZM mice treated with R848 or DMSO control were analyzed for development of lupus nephritis. A. Urine alb/cr ratio was measured serially in NZM2328 treated mice n=12 NZM R848; n=15 NZM DMSO B. Urine alb/cr ratio was measured serially in INZM treated mice. n=5 INZM DMSO; n=6 INZM R848 C. Representative photo of the glomeruli in the kidney of NZM2328 and INZM mice following treatment until moribund. Littermate control mice were harvested at the time of illness in R848 treated mice. Scale bar equals 20um. D. Renal activity score for NZM2328 and INZM mice after 2 weeks of treatment or when moribund from R848 treatment (long-term treatment). E. The moribund renal activity score for NZM2328 and INZM mice treated with R848 and DMSO was plotted versus the alb/cr ratio at euthanasia and analyzed via Pearson correlation. F. Renal Chronicity index for NZM2328 and INZM mice after 2 weeks of treatment and when moribund (long-term treatment).