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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: J Immunol. 2018 Jun 8;201(2):393–405. doi: 10.4049/jimmunol.1701588

Figure 6. TLR 7-mediated upregulation of IL-1β is not required for lupus nephritis.

Figure 6

A–C. RNA was isolated from the kidney of NZM or INZM mice treated for two weeks with DMSO control or R848. Real-time PCR was completed using primers for the genes listed. Graphs display the mean±SD for each gene as compared to the average of b-actin. Each dot represents an individual mouse. D.10 week- old NZM IL-1β KO mice were treated with R848 or DMSO control and survival was plotted. n=9 NZM IL-1β −/− DMSO; n= 8 NZM IL-1β −/− R848 E. Anti-dsDNA IgG in serum at 2 weeks of treatment. n=8 NZM IL-1β −/− R848; n=8 NZM IL-1β −/− DMSO. F. Representative photomicrograph of the glomeruli in the kidney of moribund NZM IL-1β −/− mice treated with R848 or DMSO. Littermate controls were harvested when R848 treated mice were moribund. Scale bar equals 20um. G. Renal activity score for NZM IL-1β−/− mice when moribund. H. Renal chronicity index for mice in G.